Original Article
J Korean Hip Soc 2008; 20(4): 320-325
Published online December 1, 2008
© The Korean Hip Society
무혈성 괴사에 이환된 대퇴골두 연골세포의 세포외 기질 mRNA 발현
정환용∙이우석∙김상범∙배인탁∙박원기
건양대학교 의과대학 정형외과학교실
The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis
Correspondence to : 이우석
대전광역시 서구 가수원동 685 건양대학교 의과대학 정형외과학교실
TEL: 82-42-600-6903
FAX: 82-42-545-2373
E-mail: wsleeos@kyuh.co.kr
* 본 논문은 2005년도 건양대학교 명곡 학술연구비에 지원을 받았음.
Purpose: The aim of this study was to evaluate the expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
Materials and Methods: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF.
Results: The chondrocytes of the AVN group showed decreased expressions of type Ⅱ collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
Conclusion: The cartilage matrix’s formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.
Keywords Avacular necrosis, Chondrocytes, Type II collagen, Aggrecan, VEGF-A, PEDF
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Original Article
J Korean Hip Soc 2008; 20(4): 320-325
Published online December 1, 2008 https://doi.org/10.5371/jkhs.2008.20.4.320
Copyright © The Korean Hip Society.
무혈성 괴사에 이환된 대퇴골두 연골세포의 세포외 기질 mRNA 발현
정환용∙이우석∙김상범∙배인탁∙박원기
건양대학교 의과대학 정형외과학교실
The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis
Whan-Young Chung, M.D., Woo-Suk Lee, M.D., Sang-Bum Kim, M.D., In-Tak Bae, M.D., Won-Ki Park, M.D.
Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea
Correspondence to:이우석
대전광역시 서구 가수원동 685 건양대학교 의과대학 정형외과학교실
TEL: 82-42-600-6903
FAX: 82-42-545-2373
E-mail: wsleeos@kyuh.co.kr
* 본 논문은 2005년도 건양대학교 명곡 학술연구비에 지원을 받았음.
Abstract
Purpose: The aim of this study was to evaluate the expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
Materials and Methods: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type Ⅱ collagen, aggrecan, VEGF-A and PEDF.
Results: The chondrocytes of the AVN group showed decreased expressions of type Ⅱ collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
Conclusion: The cartilage matrix’s formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.
Keywords: Avacular necrosis, Chondrocytes, Type II collagen, Aggrecan, VEGF-A, PEDF
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